Nexium 24HR Acid Reducer Heartburn Relief ClearMinis Capsules with Esomeprazole Magnesium contain all the power of Nexium 24HR heartburn medicine in an approximately 38% smaller pill that is easy to swallow. Just one Nexium 24HR ClearMinis capsule a day provides complete all day, all night protection from heartburn (1). Part of a group of medications called proton pump inhibitors (PPIs), Nexium 24HR capsules contain a delayed release formula with esomeprazole magnesium to block acid at the source, turning your body’s acid pumps from on to off for complete heartburn protection (2). Like other PPIs, Nexium acid reducers may take from 1 to 4 days to reach full effect, but relief lasts for 24 hours, letting you power through your day and sleep peacefully through the night without heartburn interruptions